I hunt grouse up north mainly. When shooting them off the ground or a branch I aim to miss so that just a few pellets remove the head. I've been using the same gun and shells for this for probably 10 years so I've figured out how it hits. It took a couple seasons to get there however, so yes I did pepper a few in the beginning.
I often put a #5 behind the #6 for a longer distance wingshot in the thick stuff, which is extremely rare where I hunt.