Powder never fully ignites before the bullet leaves the gun, that is why you need faster burning powders with shorter barrels to maintain muzzle velocity.
The case containing the powder and closed with a bullet is a pressure vessel, it is as simple as that. The ignition of the powder makes an explosion of gases that pushes the bullet out the barrel. ET1 you mention that this pressure occurs after the bullet starts moving, I don't have a problem with that, what I have a problem with is that you make it seem as though the pressure is highest as the bullet is 6in down the barrel, which would have the pressure vessel now about 3 times the original volume, which would keep a lower pressure than at original ignition.
Once you drill a hole and tap it in the barrel you do make it weaker, but not by any amount that would cause a failure let alone with a screw in place or not. The screw in place is not molecularity part of the barrel and therefore has no impact on the strength of the barrel. If the barrel were layers that the screws were holding together then maybe, but a solid piece of steel with 2 tiny holes in it does not significantly change the strength of the barrel.