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April 10th, 2015, 12:12 PM
#41

Originally Posted by
last5oh_302
Just picked up Bravecto (6 month supply-2 pills) and it was 104 bucks, so a little more for the Heartguard and Bravecto together compared to Revolution which also covers heartworm but doesn't cover black legged ticks.
might be the better choice of the new chewables (based on what the manufactures were able to claim):
Bravecto demonstrated
≥ 93%effectiveness against Dermacentor variabilis, Ixodes scapularis and Rhipicephalussanguineus ticks 48 hours post-infestation for 12 weeks. Bravecto demonstrated ≥90% effectiveness against Amblyomma americanum 72 hours post-infestation
for 8 weeks, but failed to demonstrate ≥90% effectiveness beyond 8 weeks.
in any case, the tick needs to bite before the drug starts doing anything. and, that leaves a couple of hours where the tick can get somewhere else...
Last edited by Waftrudnir; April 10th, 2015 at 12:14 PM.
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April 10th, 2015 12:12 PM
# ADS
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April 10th, 2015, 12:23 PM
#42

Originally Posted by
Waftrudnir
might be the better choice of the new chewables (based on what the manufactures were able to claim):
Bravecto demonstrated
≥ 93%effectiveness against Dermacentor variabilis, Ixodes scapularis and Rhipicephalussanguineus ticks 48 hours post-infestation for 12 weeks. Bravecto demonstrated ≥90% effectiveness against Amblyomma americanum 72 hours post-infestation
for 8 weeks, but failed to demonstrate ≥90% effectiveness beyond 8 weeks.
in any case, the tick needs to bite before the drug starts doing anything. and, that leaves a couple of hours where the tick can get somewhere else...
It kills the tick.
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April 10th, 2015, 12:42 PM
#43

Originally Posted by
last5oh_302
It kills the tick.
I don't like the head line, but the concept is worth a thought
http://www.borreliose-nachrichten.de..._-Bravecto.pdf
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April 10th, 2015, 01:14 PM
#44

Originally Posted by
Waftrudnir
It has great reviews. Sure it doesn't repel (I knew this) but it does kill ticks within 12 hours. They've been using it in the states for the last couple of years, and in Europe they've been using it for years before it got to the states. People find dead dried up ticks on their dogs, and I've yet to see a bad review on the stuff. I guess my vet has some experience with it since he ordered it but I didn't get a chance to talk to him about it.
It isn't the perfect solution, but it's the best choice for me with my house dog. It will be nice to get away from a topical for a change.
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April 10th, 2015, 08:56 PM
#45

Originally Posted by
Waftrudnir
Vet told me he sells Nexgard for a year. No issues or negative feedback so far. It does not repel ticks (only kills them).I guess people have stated differently, but the drug application reads: "NEXGARD was >97% effective against adult D. variabilis, when measured 48 hours after infestation, for 30 days."
Problem is there is no mentioning of deer ticks (Ixodes)!
Revolution is supposed to be also good against dog ticks, but unfortunately my dog picked up plenty of ticks. In retrospect, this is not surprising:
Lyme disease is an infection caused by the corkscrew-shaped bacteria, Borrelia burgdorferi. In Ontario, these bacteria are spread by the bite of blacklegged ticks (formerly called deer ticks), Ixodes scapularis. The blacklegged tick can be found sporadically throughout the province....
In Ontario, blacklegged ticks are more commonly found in rural areas along the north shores of Lake Erie, Lake Ontario, and the St. Lawrence River. Locations with established blacklegged tick populations infected with Lyme disease include: Long Point Provincial Park, Turkey Point Provincial Park, Rondeau Provincial Park, Pinery Provincial Park, Rouge Valley, Point Pelee National Park, Prince Edward Point National Wildlife Area, Wainfleet Bog Conservation Area, and the Thousand Islands National Park area. The precise boundaries of these established tick populations are difficult to define but it is anticipated that some of these populations will continue to expand into neighbouring areas. Blacklegged ticks are also known to feed on migratory birds and as a result, they can be transported throughout the province. Therefore, while the potential is low, it is possible for people to encounter blacklegged ticks, or to be infected with Lyme disease from the bite of an infected blacklegged tick, almost anywhere in the province.
In well-controlled laboratory studies, NexGard demonstrated >97% effectivenessagainst Dermacentor variabilis,>94% effectiveness against Ixodes scapularis, and >93%effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. At72 hours post-infestation, NexGard demonstrated >97% effectivness against Amblyommaamericanum for 30 days.
the above is from the Nexgard product info in the link in my previous post
Last edited by be2man; April 10th, 2015 at 09:18 PM.
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April 10th, 2015, 09:12 PM
#46
A good overview of Lyme Disease in dogs
http://www.capcvet.org/capc-recommen...s/lyme-disease
An excerpt
Host Association and Transmission between Hosts
- Pets become infected with B. burgdorferi upon inoculation of organisms by tick feeding. Ticks are not able to transmit infection immediately upon first attachment to a host, but instead require a period of approximately 24 to 48 hours of initial feeding before organisms are able to pass across the salivary glands and into the vertebrate host.
- Although experimentally infected dogs have been shown capable of infecting ticks and thus theoretically could serve as a reservoir host of B. burgdorferi, dogs are not considered an important source of human infection due to the feeding behaviors of I. scapularis and I. pacificus.
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April 10th, 2015, 09:51 PM
#47

Originally Posted by
be2man
In well-controlled laboratory studies, NexGard demonstrated >97% effectivenessagainst Dermacentor variabilis,>94% effectiveness against Ixodes scapularis, and >93%effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. At72 hours post-infestation, NexGard demonstrated >97% effectivness against Amblyommaamericanum for 30 days.
the above is from the Nexgard product info in the link in my previous post
interesting: the original (2013) application with FDA does not include it and neither does the supplemental NADA (2014),
http://www.fda.gov/downloads/AnimalV.../UCM377867.pdf
http://www.fda.gov/downloads/AnimalV.../UCM377867.pdfhttp://www.fda.gov/downloads/AnimalV.../UCM399805.pdf the EMA assessed already deer ticks in 2013
http://www.ema.europa.eu/docs/en_GB/...C500158265.pdf
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April 10th, 2015, 10:05 PM
#48

Originally Posted by
be2man
A good overview of Lyme Disease in dogs
...
- Pets become infected with B. burgdorferi upon inoculation of organisms by tick feeding. Ticks are not able to transmit infection immediately upon first attachment to a host, but instead require a period of approximately 24 to 48 hours of initial feeding before organisms are able to pass across the salivary glands and into the vertebrate host.
- ...
That is not only true for borreliosis, but for other nice things those buggers can carry. under 24h is a good chance that not much got transmitted, over 72hrs it is pretty much guarantied that the host has it
that's why you should get them out immediately. even if parts stay in the skin, which can be dealt with later.
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April 10th, 2015, 10:11 PM
#49
Likely has been some additional studies since the FDA submitted data. A search of "Efficacy of Afoxolaner against Ixodes Scapularis in dogs" had a lot of results
http://www.ncbi.nlm.nih.gov/pubmed/24685321
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April 11th, 2015, 05:45 AM
#50

Originally Posted by
last5oh_302
Just picked up Bravecto (6 month supply-2 pills) and it was 104 bucks,
That's a show stopper for me, with 4 dogs that would be a huge cost increase. Especially since we don't have kids and cats to worry about using a topical application. The worse we get are that the 'oils' collect dust from the sand box and they look like a skunk of for a few days.
Thankfully we have access to the US market, and I can do a 3 month protection for $15. We've been using 'Liberty 50' for about 10 yrs now and never have had a tick issue.
Mind you we don't have anywhere near the problem you folks in the S/W are having. Last year was the first year we found ticks in Apr. We usually don't have to start the prevention till May, so it is getting worse here and we've done our first application already.